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Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity
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SYSNO ASEP 0471527 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity Tvůrce(i) Brož, Václav (BC-A) RID, ORCID
Kučerová, Lucie (BC-A) RID, ORCID
Rouhová, L. (CZ)
Fleischmannová, Jana (BC-A)
Strnad, Hynek (UMG-J) RID
Bryant, P. J. (US)
Žurovec, Michal (BC-A) RID, ORCIDCelkový počet autorů 7 Číslo článku 43273 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 7, FEB 23 (2017)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Drosophila ; innate immunity ; IDGF2 Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology Vědní obor RIV – spolupráce Ústav molekulární genetiky - Biochemie CEP GA14-27816S GA ČR - Grantová agentura ČR GA14-07172S GA ČR - Grantová agentura ČR Institucionální podpora BC-A - RVO:60077344 ; UMG-J - RVO:68378050 UT WOS 000394750800001 EID SCOPUS 85013860816 DOI 10.1038/srep43273 Anotace Drosophila imaginal disc growth factors (IDGFs) are a family of chitinase-like glycoproteins abundantly secreted into the hemolymph by fat body and hemocytes.We show that the prototypical member, IDGF2, is an insulin-independent trophic and protective factor in cultured insect cells as well as in intact /Drosophila/ larvae and adults. It protects cells from death caused by serum deprivation, toxicity of xenobiotics or high concentrations of extracellular adenosine (Ado) and deoxyadenosine (dAdo).Recombinant IDGF2 is able to renew the mitochondrial and cellular energy homeostasis and prevent the dissipation of mitochondrial membrane potential (delta-psi(m) in cultured cells. Transcriptional profiling supported the role of IDGF2 in energy metabolism, detoxification and innate immunity. We also show that IDGF2 is induced by injury in larval stages. The highest IDGF2 accumulation found at garland and pericardial nephrocytes is also consistent with its role in organismal detoxification. Taken together, IDGF2 has similar overall homeostatic and protective effect as mammalian serum and chitinase-like glycoproteins recently associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas.
Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2018 Elektronická adresa http://www.nature.com/articles/srep43273
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