Počet záznamů: 1  

Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity

  1. 1.
    SYSNO ASEP0471527
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevDrosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity
    Tvůrce(i) Brož, Václav (BC-A) RID, ORCID
    Kučerová, Lucie (BC-A) RID, ORCID
    Rouhová, L. (CZ)
    Fleischmannová, Jana (BC-A)
    Strnad, Hynek (UMG-J) RID
    Bryant, P. J. (US)
    Žurovec, Michal (BC-A) RID, ORCID
    Celkový počet autorů7
    Číslo článku43273
    Zdroj.dok.Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
    Roč. 7, FEB 23 (2017)
    Poč.str.15 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaDrosophila ; innate immunity ; IDGF2
    Vědní obor RIVCE - Biochemie
    Obor OECDBiochemistry and molecular biology
    Vědní obor RIV – spolupráceÚstav molekulární genetiky - Biochemie
    CEPGA14-27816S GA ČR - Grantová agentura ČR
    GA14-07172S GA ČR - Grantová agentura ČR
    Institucionální podporaBC-A - RVO:60077344 ; UMG-J - RVO:68378050
    UT WOS000394750800001
    EID SCOPUS85013860816
    DOI10.1038/srep43273
    AnotaceDrosophila imaginal disc growth factors (IDGFs) are a family of chitinase-like glycoproteins abundantly secreted into the hemolymph by fat body and hemocytes.We show that the prototypical member, IDGF2, is an insulin-independent trophic and protective factor in cultured insect cells as well as in intact /Drosophila/ larvae and adults. It protects cells from death caused by serum deprivation, toxicity of xenobiotics or high concentrations of extracellular adenosine (Ado) and deoxyadenosine (dAdo).Recombinant IDGF2 is able to renew the mitochondrial and cellular energy homeostasis and prevent the dissipation of mitochondrial membrane potential (delta-psi(m) in cultured cells. Transcriptional profiling supported the role of IDGF2 in energy metabolism, detoxification and innate immunity. We also show that IDGF2 is induced by injury in larval stages. The highest IDGF2 accumulation found at garland and pericardial nephrocytes is also consistent with its role in organismal detoxification. Taken together, IDGF2 has similar overall homeostatic and protective effect as mammalian serum and chitinase-like glycoproteins recently associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas.

    PracovištěBiologické centrum (od r. 2006)
    KontaktDana Hypšová, eje@eje.cz, Tel.: 387 775 214
    Rok sběru2018
    Elektronická adresahttp://www.nature.com/articles/srep43273
Počet záznamů: 1  

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