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Tear film lipid layer: A molecular level view

SYSNO ASEP	0468631
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Tear film lipid layer: A molecular level view
Tvůrce(i)	Cwiklik, Lukasz (UFCH-W)_{RID, ORCID}
Zdroj.dok.	Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736 Roč. 1858, č. 10 (2016), s. 2421-2430
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	tear film ; tear film lipid layer ; molecular dynamics simulations
Vědní obor RIV	CF - Fyzikální chemie a teoretická chemie
CEP	GA15-14292S GA ČR - Grantová agentura ČR
Způsob publikování	Open access
Institucionální podpora	UFCH-W - RVO:61388955
UT WOS	000382340100014
EID SCOPUS	84959144726
DOI	10.1016/j.bbamem.2016.02.020
Anotace	Human cornea is covered by an aqueous tear film, and the outermost layer of the tear film is coated by lipids. This so-called tear film lipid layer (TFLL) reduces surface tension of the tear film and helps with the film re-spreading after blinks. Alterations of tear lipids composition and properties are related to dry eye syndrome. Therefore, unveiling structural and functional properties of TFLL is necessary for understanding tear film function under both normal and pathological conditions. Key properties of TFLL, such as resistance against high lateral pressures and ability to spread at the tear film surface, are directly related to the chemical identity of TFLL lipids. Hence, a molecular-level description is required to get better insight into TFLL properties. Molecular dynamics simulations are particularly well suited for this task and they were recently used for investigating TFLL The present review discusses molecular level organization and properties of TFLL as seen by these simulation studies. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Rog. (C) 2016 Elsevier B.V. All rights reserved.
Pracoviště	Ústav fyzikální chemie J.Heyrovského
Kontakt	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Rok sběru	2017

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