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The role of protease-activated receptor type 2 in nociceptive signaling and pain
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SYSNO ASEP 0462321 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of protease-activated receptor type 2 in nociceptive signaling and pain Tvůrce(i) Mrózková, Petra (FGU-C) RID, ORCID
Paleček, Jiří (FGU-C) RID, ORCID
Špicarová, Diana (FGU-C) RID, ORCIDZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 65, č. 3 (2016), s. 357-367Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova protease-activated receptor (PAR2) ; signaling pathways ; nociception ; pain ; spinal cord Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP LH12058 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GBP304/12/G069 GA ČR - Grantová agentura ČR GA15-11138S GA ČR - Grantová agentura ČR LH15279 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora FGU-C - RVO:67985823 UT WOS 000382115700001 EID SCOPUS 84979742838 Anotace Protease-activated receptors (PARs) belong to the G-protein-coupled receptor family, that are expressed in many body tissues especially in different epithelial cells, mast cells and also in neurons and astrocytes. PARs play different physiological roles according to the location of their expression. Increased evidence supports the importance of PARs activation during nociceptive signaling and in the development of chronic pain states. This short review focuses on the role of PAR2 receptors in nociceptive transmission with the emphasis on the modulation at the spinal cord level. PAR2 are cleaved and subsequently activated by endogenous proteases such as tryptase and trypsin. In vivo, peripheral and intrathecal administration of PAR2 agonists induces thermal and mechanical hypersensitivity that is thought to be mediated by PAR2-induced release of pronociceptive neuropeptides and modulation of different receptors. PAR2 activation leads also to sensitization of transient receptor potential channels (TRP) that are crucial for nociceptive signaling and modulation. PAR2 receptors may play an important modulatory role in the development and maintenance of different pathological pain states and could represent a potential target for new analgesic treatments. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2017
Počet záznamů: 1