Počet záznamů: 1  

Composite scaffolds for cartilage tissue engineering based on natural polymers of bacterial origin, thermoplastic poly(3-hydroxybutyrate) and micro-fibrillated bacterial cellulose

  1. 1.
    SYSNO ASEP0460382
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevComposite scaffolds for cartilage tissue engineering based on natural polymers of bacterial origin, thermoplastic poly(3-hydroxybutyrate) and micro-fibrillated bacterial cellulose
    Tvůrce(i) Akaraonye, E. (GB)
    Filip, J. (CZ)
    Šafaříková, Miroslava (BC-A) RID
    Salih, V. (GB)
    Keshavarz, T. (GB)
    Knowles, J.C. (GB)
    Roy, I. (GB)
    Zdroj.dok.Polymer International. - : Wiley - ISSN 0959-8103
    Roč. 65, č. 7 (2016), s. 780-791
    Poč.str.12 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovapolyhydroxyalkanoates ; poly(3-hydroxybutyrate) ; bacterial cellulose ; micro-fibrillated cellulose ; tissue engineering scaffold ; composite materials
    Vědní obor RIVCD - Makromolekulární chemie
    Institucionální podporaBC-A - RVO:60077344
    UT WOS000377500300007
    EID SCOPUS84981764770
    DOI10.1002/pi.5103
    AnotaceCartilage tissue engineering is an emerging therapeutic strategy that aims to regenerate damaged cartilage caused by disease, trauma, ageing or developmental disorder. Since cartilage lacks regenerative capabilities, it is essential to develop approaches that deliver the appropriate cells, biomaterials and signalling factors to the defect site. Materials and fabrication technologies are therefore critically important for cartilage tissue engineering in designing temporary, artificial extracellular matrices (scaffolds), which support 3D cartilage formation. Hence, this work aimed to investigate the use of poly(3-hydroxybutyrate)/microfibrillated bacterial cellulose (P(3HB)/MFC) composites as 3D-scaffolds for potential application in cartilage tissue engineering. The compression moulding/particulate leaching technique employed in the study resulted in good dispersion and a strong adhesion between the MFC and the P(3HB) matrix. Furthermore, the composite scaffold produced displayed better mechanical properties than the neat P(3HB) scaffold. On addition of 10, 20, 30 and 40 wt% MFC to the P(3HB) matrix, the compressive modulus was found to have increased by 35%, 37%, 64% and 124%, while the compression yield strength increased by 95%, 97%, 98% and 102% respectively with respect to neat P(3HB). Both cell attachment and proliferation were found to be optimal on the polymer-based 3D composite scaffolds produced, indicating a non-toxic and highly compatible surface for the adhesion and proliferation of mouse chondrogenic ATDC5 cells. The large pores sizes (60-83 mu m) in the 3D scaffold allowed infiltration and migration of ATDC5 cells deep into the porous network of the scaffold material. Overall this work confirmed the potential of P(3HB)/MFC composites as novel materials in cartilage tissue engineering.
    PracovištěBiologické centrum (od r. 2006)
    KontaktDana Hypšová, eje@eje.cz, Tel.: 387 775 214
    Rok sběru2017
Počet záznamů: 1  

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