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Cubozoan genome illuminates functional diversification of opsins and photoreceptor evolution
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SYSNO ASEP 0455852 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cubozoan genome illuminates functional diversification of opsins and photoreceptor evolution Tvůrce(i) Liegertová, Michaela (UMG-J)
Pergner, Jiří (UMG-J)
Kozmiková, Iryna (UMG-J) RID
Fabian, Peter (UMG-J)
Pombinho, António R. (UMG-J)
Strnad, Hynek (UMG-J) RID
Pačes, Jan (UMG-J) RID, ORCID
Vlček, Čestmír (UMG-J) RID
Bartůněk, Petr (UMG-J) RID
Kozmik, Zbyněk (UMG-J) RIDZdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 5, Jul 8 (2015)Poč.str. 19 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Cubozoan genome ; opsins ; photoreceptor ; evolution Vědní obor RIV EB - Genetika a molekulární biologie CEP GAP305/10/2141 GA ČR - Grantová agentura ČR LO1220 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMG-J - RVO:68378050 UT WOS 000357577400002 DOI 10.1038/srep11885 Anotace Animals sense light primarily by an opsin-based photopigment present in a photoreceptor cell. Cnidaria are arguably the most basal phylum containing a well-developed visual system. The evolutionary history of opsins in the animal kingdom has not yet been resolved. Here, we study the evolution of animal opsins by genome-wide analysis of the cubozoan jellyfish Tripedalia cystophora, a cnidarian possessing complex lens-containing eyes and minor photoreceptors. A large number of opsin genes with distinct tissue-and stage-specific expression were identified. Our phylogenetic analysis unequivocally classifies cubozoan opsins as a sister group to c-opsins and documents lineage-specific expansion of the opsin gene repertoire in the cubozoan genome. Functional analyses provided evidence for the use of the Gs-cAMP signaling pathway in a small set of cubozoan opsins, indicating the possibility that the majority of other cubozoan opsins signal via distinct pathways. Additionally, these tests uncovered subtle differences among individual opsins, suggesting possible fine-tuning for specific photoreceptor tasks. Based on phylogenetic, expression and biochemical analysis we propose that rapid lineage-and species-specific duplications of the intron-less opsin genes and their subsequent functional diversification promoted evolution of a large repertoire of both visual and extraocular photoreceptors in cubozoans. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2016
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