Počet záznamů: 1

Comparison of intraspinal and intrathecal implantation of induced pluripotent stem cell-derived neural precursors for the treatment of spinal cord injury in rats

SYSNO ASEP	0454661
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Comparison of intraspinal and intrathecal implantation of induced pluripotent stem cell-derived neural precursors for the treatment of spinal cord injury in rats
Tvůrce(i)	Amemori, Takashi (UEM-P)_RID Růžička, Jiří (UEM-P) Romanyuk, Nataliya (UEM-P)_RID Jhanwar-Uniyal, M. (US) Syková, Eva (UEM-P)_RID Jendelová, Pavla (UEM-P)_{RID, ORCID}
Celkový počet autorů	6
Zdroj.dok.	Stem Cell Research & Therapy. - : BioMed Central Roč. 6, Dec (2015), s. 257
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	spinal cord injury ; human induced pluripotent stem cells ; cell therapy ; cell application route
Vědní obor RIV	FH - Neurologie, neurochirurgie, neurovědy
CEP	LH12024 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	UEM-P - RVO:68378041
UT WOS	000366894600001
EID SCOPUS	84951846358
DOI	10.1186/s13287-015-0255-2
Anotace	In the present study, we administered neural precursors derived from induced pluripotent stem cells (iPS-NPs) either intraspinally into the lesion center or intrathecally into the subarachnoid space of rats with a balloon-induced spinal cord compression lesion. Both treatments facilitated the functional locomotor recovery of rats with SCI. Intrathecal application of iPS-NPs has a positive therapeutic influence (resulting in locomotor improvement, moderate tissue sparing and axonal sprouting) on SCI through a paracrine mechanism that does not require the presence of cells in the tissue. However, the extended survival of intraspinally grafted cells in the spinal cord may promote long-term spinal cord tissue regeneration.
Pracoviště	Ústav experimentální medicíny
Kontakt	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Rok sběru	2016

Počet záznamů: 1