Počet záznamů: 1

Gene expression profiling of changes induced by maternal diabetes in the embryonic heart

SYSNO ASEP	0453296
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Gene expression profiling of changes induced by maternal diabetes in the embryonic heart
Tvůrce(i)	Bohuslavová, Romana (BTO-N)_RID Škvorová, Lada (BTO-N) Čerychová, Radka (BTO-N) Pavlínková, Gabriela (BTO-N)_{RID, ORCID}
Zdroj.dok.	Reproductive Toxicology. - : Elsevier - ISSN 0890-6238 Roč. 57, NOV 2015 (2015), s. 147-156
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	Diabetic embryopathy ; Vascular endothelial growth factor A (VEGF-A) ; Gene expression ; Cardiovascular defects
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GA301/09/0117 GA ČR - Grantová agentura ČR
	ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	BTO-N - RVO:86652036
CEZ	AV0Z50520701 - BTO-N (2007-2013)
UT WOS	000360322300017
DOI	10.1016/j.reprotox.2015.06.045
Anotace	Cardiovascular defects are one of the most common congenital defects associated with maternal diabetes. Based on whole embryo gene expression microarray analysis, 11 genes were chosen for temporal expression analysis of diabetes-exposed hearts. The majority of the selected genes were deregulated in diabetes-exposed hearts compared to our controls at E13.5, E14.5, and E18.5. We showed increased hypoxia and HIF-1 alpha protein levels in diabetes-exposed hearts at E10.5, which is a critical time point for the induction of developmental defects associated with diabetic embryopathy. Additionally, we found increased cardiac Vegfa levels that might trigger developmental abnormalities associated with diabetic embryopathy. Our results show that maternal diabetes affects the temporal expression pattern of gene encoding molecules involved in heart development and tissue remodelling and that these molecules might affect heart maturation processes and thus, the final outcome of diabetic pregnancies. (C) 2015 Elsevier Inc. All rights reserved.
Pracoviště	Biotechnologický ústav
Kontakt	Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
Rok sběru	2016

Počet záznamů: 1