Počet záznamů: 1  

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

  1. 1.
    SYSNO ASEP0449679
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevBranched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease
    Tvůrce(i) Lake, A.D. (US)
    Novák, Petr (BC-A) RID, ORCID
    Shipkova, P. (US)
    Aranibar, N. (US)
    Robertson, D.G. (US)
    Reily, M.D. (US)
    Lehman-McKeeman, L.D. (US)
    Vaillancourt, R.R. (US)
    Cherrington, N.J. (US)
    Zdroj.dok.Amino Acids. - : Springer - ISSN 0939-4451
    Roč. 47, č. 3 (2015), s. 603-615
    Poč.str.13 s.
    Jazyk dok.eng - angličtina
    Země vyd.AT - Rakousko
    Klíč. slovaBranched chain amino acid ; nonalcoholic fatty liver disease ; nonalcoholic steatohepatitis ; metabolomics and transcriptomics
    Vědní obor RIVCE - Biochemie
    Institucionální podporaBC-A - RVO:60077344
    UT WOS000349390700015
    DOI10.1007/s00726-014-1894-9
    AnotaceNonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing clinical significance. The pathological progression of the disease from simple steatosis to nonalcoholic steatohepatitis (NASH) has been well defined, however, the contribution of altered branched chain amino acid metabolomic profiles to the progression of NAFLD is not known. The three BCAAs: leucine, isoleucine and valine are known to mediate activation of several important hepatic metabolic signaling pathways ranging from insulin signaling to glucose regulation. The purpose of this study is to profile changes in hepatic BCAA metabolite levels with transcriptomic changes in the progression of human NAFLD to discover novel mechanisms of disease progression. Metabolomic and transcriptomic data sets representing the spectrum of human NAFLD (normal, steatosis, NASH fatty, and NASH not fatty livers) were utilized for this study.
    PracovištěBiologické centrum (od r. 2006)
    KontaktDana Hypšová, eje@eje.cz, Tel.: 387 775 214
    Rok sběru2016
Počet záznamů: 1  

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