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Instrument platforms for nano liquid chromatography
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SYSNO ASEP 0449307 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Instrument platforms for nano liquid chromatography Tvůrce(i) Šesták, Jozef (UIACH-O) ORCID
Moravcová, Dana (UIACH-O) RID, ORCID
Kahle, Vladislav (UIACH-O) RIDCelkový počet autorů 3 Zdroj.dok. Journal of Chromatography A. - : Elsevier - ISSN 0021-9673
Roč. 1421, NOV (2015), s. 2-17Poč.str. 16 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova nano liquid chromatography ; splitless gradient generation ; nano LC platforms Vědní obor RIV CB - Analytická chemie, separace CEP VG20112015021 GA MV - Ministerstvo vnitra Institucionální podpora UIACH-O - RVO:68081715 UT WOS 000364886000002 DOI 10.1016/j.chroma.2015.07.090 Anotace tThe history of liquid chromatography started more than a century ago and miniaturization and automa-tion are two leading trends in this field. Nanocolumn liquid chromatography (nano LC) and largelysynonymous capillary liquid chromatography (capillary LC) are the most recent results of this processwhere miniaturization of column dimensions and sorbent particle size play crucial role. Very interestingresults achieved in the research of extremely miniaturized LC columns at the end of the last centurylacked distinctive raison d’être and only advances in mass spectrometry brought a real breakthrough.Configuration of nano LC-electrospray ionization mass spectrometry (LC-ESI-MS) has become a basictool in bioanalytical chemistry, especially in proteomics. This review discusses and summarizes past andcurrent trends in the realization of nano liquid chromatography (nano LC) platforms. Special attention isgiven to the mobile phase delivery under nanoflow rates (isocratic, gradient) and sample injection to thenanocolumn. Available detection techniques applied in nano LC separations are also briefly discussed.We followed up the key themes from the original scientific reports over gradual improvements up to thecontemporary commercial solutions. Pracoviště Ústav analytické chemie Kontakt Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Rok sběru 2016 Elektronická adresa http://hdl.handle.net/11104/0250900
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