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A Difference in Fatty Acid Composition of Isocaloric High-Fat Diets Alters Metabolic Flexibility in Male C57BL/6JOlaHsd Mice
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SYSNO ASEP 0446423 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A Difference in Fatty Acid Composition of Isocaloric High-Fat Diets Alters Metabolic Flexibility in Male C57BL/6JOlaHsd Mice Tvůrce(i) Duivenvoorde, L. P. M. (NL)
van Schothorst, E. M. (NL)
Swarts, H. M. (NL)
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Steenbergh, E. (NL)
Termeulen, S. (NL)
Kopecký, Jan (FGU-C) RID, ORCID
Keijer, J. (NL)Zdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 10, č. 6 (2015), e0128515Poč.str. 19 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova PUFA ; satureted fatty acids ; high fat diet ; metabolic flexibility ; indirect calorimetry Vědní obor RIV FB - Endokrinologie, diabetologie, metabolizmus, výživa CEP 7E10059 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora FGU-C - RVO:67985823 UT WOS 000356835800016 DOI 10.1371/journal.pone.0128515 Anotace The aim of this study was to determine the effect of high-fat diets with different fatty acid compositions, but similar n6/n3 ratio (with either predominantly PUFAs (HFpu diet) or predominantly SFAs (HFs diet)), on metabolic flexibility. We found that the HFs diet, compared to the HFpu diet, increased mean adipocyte size, liver damage, and ectopic lipid storage in liver and muscle; although, we did not find differences in body weight, total adiposity, adipose tissue health, serum adipokines, whole body energy balance, or circadian rhythm between HFs and HFpu mice. HFs mice were, furthermore, less flexible in their response to both fasting- re-feeding and OxR, while glucose tolerance was indistinguishable. To conclude, the HFs versus the HFpu diet increased ectopic fat storage, liver damage, and mean adipocyte size and reduced metabolic flexibility in male mice. This study underscores the physiological relevance of indirect calorimetry-based challenge tests Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2016
Počet záznamů: 1