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Instability restricts signaling of multiple fibroblast growth factors
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SYSNO ASEP 0445257 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Instability restricts signaling of multiple fibroblast growth factors Tvůrce(i) Buchtová, Marcela (UZFG-Y) RID, ORCID
Chaloupková, R. (CZ)
Zakrzewska, M. (PL)
Veselá, I. (CZ)
Celá, Petra (UZFG-Y) RID
Barathová, J. (CZ)
Gudernová, I. (CZ)
Zajíčková, R. (CZ)
Trantírek, L. (CZ)
Martin, J. (US)
Kostas, M. (PL)
Otlewski, J. (PL)
Damborský, J. (CZ)
Kozubík, Alois (BFU-R) RID, ORCID
Wiedlocha, A. (NO)
Krejčí, P. (CZ)Zdroj.dok. Cellular and Molecular Life Sciences - ISSN 1420-682X
Roč. 72, č. 12 (2015), s. 2445-2459Poč.str. 15 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova fibroblast growth factor ; FGF ; unstable Vědní obor RIV EA - Morfologické obory a cytologie CEP GA14-31540S GA ČR - Grantová agentura ČR GBP302/12/G157 GA ČR - Grantová agentura ČR Institucionální podpora UZFG-Y - RVO:67985904 ; BFU-R - RVO:68081707 UT WOS 000354883500014 EID SCOPUS 84929710353 DOI 10.1007/s00018-015-1856-8 Anotace Fibroblast growth factors (FGFs) deliver extracellular signals that govern many developmental and regenerative processes, but the mechanisms regulating FGF signaling remain incompletely understood. Here, we explored the relationship between intrinsic stability of FGF proteins and their biological activity for all 18 members of the FGF family. We report that FGF1, FGF3, FGF4, FGF6, FGF8, FGF9, FGF10, FGF16, FGF17, FGF18, FGF20, and FGF22 exist as unstable proteins, which are rapidly degraded in cell cultivation media. Biological activity of FGF1, FGF3, FGF4, FGF6, FGF8, FGF10, FGF16, FGF17, and FGF20 is limited by their instability, manifesting as failure to activate FGF receptor signal transduction over long periods of time, and influence specific cell behavior in vitro and in vivo. Stabilization via exogenous heparin binding, introduction of stabilizing mutations or lowering the cell cultivation temperature rescues signaling of unstable FGFs. Thus, the intrinsic ligand instability is an important elementary level of regulation in the FGF signaling system. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2016
Počet záznamů: 1