Počet záznamů: 1

Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours

SYSNO ASEP	0444229
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours
Tvůrce(i)	Mo, S. (GB) Carlisle, R. (GB) Laga, Richard (UMCH-V)_{RID, ORCID} Myers, R. (GB) Graham, S. (GB) Cawood, R. (GB) Ulbrich, Karel (UMCH-V)_RID Seymour, L. (GB) Coussios, C. C. (GB)
Zdroj.dok.	Journal of Controlled Release. - : Elsevier - ISSN 0168-3659 Roč. 210, 28 July (2015), s. 10-18
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	delivery ; density ; tumour
Vědní obor RIV	CE - Biochemie
CEP	EE2.3.30.0029 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	UMCH-V - RVO:61389013
UT WOS	000356238700002
EID SCOPUS	84929611293
DOI	10.1016/j.jconrel.2015.05.265
Anotace	Nanomedicines have provided fresh impetus in the fight against cancer due to their selectivity and power. However, these agents are limited when delivered intravenously due to their rapid clearance from the bloodstream and poor passage from the bloodstream into target tumours. Here we describe a novel stealthing strategy which addresses both these limitations and thereby demonstrate that both the passive and mechanically-mediated tumour accumulation of the model nanomedicine adenovirus (Ad) can be substantially enhanced. In our strategy gold nanoparticles were thoroughly modified with 2 kDa polyethyleneglycol (PEG) and then linked to Ad via a single reduction-cleavable 5 kDa PEG. The resulting Ad–gold–PEG construct was compared to non-modified Ad or conventionally stealthed Ad–poly[N-(2-hydroxypropyl)methacrylamide] (Ad–PHPMA). Notably, although Ad–gold–PEG was of similar size and surface charge to Ad–PHPMA the increase in density, resulting from the inclusion of the gold nanoparticles, provided a substantial enhancement of ultrasound-mediated transport. In an in vitro tumour mimicking phantom, the level and distance of Ad–gold–PEG transport was shown to be substantially greater than achieved with Ad–PHPMA. In in vivo studies 0.1% of an unmodified Ad dose was shown to accumulate in tumours, whereas over 12% of the injected dose was recovered from the tumours of mice treated with Ad–gold–PEG and ultrasound. Ultimately, a significant increase in anti-tumour efficacy resulted from this strategy. This stealthing and density-increasing technology could ultimately enhance clinical utility of intravenously delivered nanoscale medicines including viruses, liposomes and antibodies.
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2016

Počet záznamů: 1