Počet záznamů: 1  

Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila – A role for dFoxO?

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    SYSNO ASEP0444024
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevKnockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila – A role for dFoxO?
    Tvůrce(i) Bednářová, Andrea (BC-A) RID, ORCID
    Kodrík, Dalibor (BC-A) RID, ORCID
    Krishnan, N. (US)
    Celkový počet autorů3
    Zdroj.dok.Comparative Biochemistry and Physiology Part C. - : Elsevier - ISSN 1532-0456
    Roč. 171, May 01 (2015), s. 8-14
    Poč.str.7 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaadipokinetic hormone ; Drosophila ; hydrogen peroxide
    Vědní obor RIVED - Fyziologie
    CEPGA14-07172S GA ČR - Grantová agentura ČR
    LH14047 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    Institucionální podporaBC-A - RVO:60077344
    UT WOS000354343400002
    EID SCOPUS84925783892
    DOI10.1016/j.cbpc.2015.03.006
    AnotaceSignaling pathways of insect adipokinetic hormones (AKHs) in anti-oxidative response are unclear. Exposure to hydrogen peroxide (HP) revealed that AKH-RNAi flies showed significantly higher mortality than AKH-oex or control lines. AKH-RNAi flies had significantly less dFoxO transcript and translated protein compared to control and AKH-oex flies in un-challenged condition as well as when challenged with HP. Sestrin – a major antioxidant defense protein and one of the targets of dFoxO – was also significantly down-regulated in AKH-RNAi flies (both unchallenged and challenged with HP) compared to control flies and flies with over-expressed AKH. These findings imply that dFoxO may act downstream of AKH as a transcription factor to mediate response to OS in D. melanogaster.
    PracovištěBiologické centrum (od r. 2006)
    KontaktDana Hypšová, eje@eje.cz, Tel.: 387 775 214
    Rok sběru2016
    Elektronická adresahttp://www.sciencedirect.com/science/article/pii/S1532045615000265
Počet záznamů: 1