Počet záznamů: 1

Lipid signaling in adipose tissue: Connecting inflammation & metabolism

SYSNO ASEP	0443441
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Lipid signaling in adipose tissue: Connecting inflammation & metabolism
Tvůrce(i)	Masoodi, M. (CH) Kuda, Ondřej (FGU-C)_{RID, ORCID, SAI} Rossmeisl, Martin (FGU-C)_{RID, ORCID} Flachs, Pavel (FGU-C)_RID Kopecký, Jan (FGU-C)_{RID, ORCID}
Zdroj.dok.	Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. - : Elsevier - ISSN 1388-1981 Roč. 1851, č. 4 (2015), s. 503-518
Poč.str.	16 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	adipocyte ; futile substrate cycle ; macrophage
Vědní obor RIV	FB - Endokrinologie, diabetologie, metabolizmus, výživa
CEP	GA13-00871S GA ČR - Grantová agentura ČR
	7E12073 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	LH14040 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000350186800018
EID SCOPUS	84922569444
DOI	10.1016/j.bbalip.2014.09.023
Anotace	Accumulation of immune cells, especially macrophages, and macrophage polarization from M2 to M1 state, affect intrinsic WAT signaling, namely anti-inflammatory and proinflammatory cytokines, fatty acids (FA), and lipid mediators derived from both n−6 and n−3 long-chain PUFA. Studies in mice suggest that (i) transient accumulation of M2 macrophages could be essential for the control of tissue FA levels during activation of lipolysis, (ii) currently unidentified M2 macrophage-borne signaling molecule(s) could inhibit lipolysis and re-esterification of lipolyzed FA back to triacylglycerols (TAG/FA cycle), and (iii) the egress of M2 macrophages from rebuilt WAT and removal of the negative feedback regulation could allow for a full unmasking of metabolic activities of adipocytes. Thus, M2 macrophages could support remodeling of WAT to a tissue containing metabolically flexible adipocytes endowed with a high capacity of both TAG/FA cycling and oxidative phosphorylation. This situation could be exemplified by a combined intervention using mild calorie restriction and dietary supplementation with EPA/DHA, which enhances the formation of “healthy” adipocytes
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2016

Počet záznamů: 1