Počet záznamů: 1

DNA and RNA Quadruplex-Binding Proteins

SYSNO ASEP	0442425
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	Záznam nebyl označen do RIV
Poddruh J	Článek ve WOS
Název	DNA and RNA Quadruplex-Binding Proteins
Tvůrce(i)	Brázda, Václav (BFU-R)_{RID, ORCID} Haroniková, Lucia (BFU-R) Liao, J.C.C. (AU) Fojta, Miroslav (BFU-R)_{RID, ORCID}
Celkový počet autorů	4
Zdroj.dok.	International Journal of Molecular Sciences. - : MDPI Roč. 15, č. 10 (2014), s. 17493-17517
Poč.str.	25 s.
Forma vydání	Tištěná - P
Jazyk dok.	eng - angličtina
Země vyd.	CH - Švýcarsko
Klíč. slova	DNA quadruplex ; RNA quadruplex ; telomere
Vědní obor RIV	BO - Biofyzika
CEP	GBP206/12/G151 GA ČR - Grantová agentura ČR
Institucionální podpora	BFU-R - RVO:68081707
UT WOS	000348039400008
DOI	10.3390/ijms151017493
Anotace	Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i-Motifs, minor groove quadruplexes, G-quadruplexes, etc.), the best described are G-quadruplexes which are featured by Hoogsteen base-paring. Sequences with the potential to form quadruplexes are widely present in genome of all organisms. They are found often in repetitive sequences such as telomeric ones, and also in promoter regions and 5' non-coding sequences. Recently, many proteins with binding affinity to G-quadruplexes have been identified. One of the initially portrayed G-rich regions, the human telomeric sequence (TTAGGG)(n), is recognized by many proteins which can modulate telomerase activity. Sequences with the potential to form G-quadruplexes are often located in promoter regions of various oncogenes. The NHE III1 region of the c-MYC promoter has been shown to interact with nucleolin protein as well as other G-quadruplex-binding proteins. A number of G-rich sequences are also present in promoter region of estrogen receptor alpha.
Pracoviště	Biofyzikální ústav
Kontakt	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Rok sběru	2015

Počet záznamů: 1