Počet záznamů: 1  

Functional organization of the genome may shape the species boundary in the house mouse

  1. 1.
    SYSNO ASEP0441360
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevFunctional organization of the genome may shape the species boundary in the house mouse
    Tvůrce(i) Janoušek, Václav (UBO-W) ORCID
    Munclinger, P. (CZ)
    Wang, L. (US)
    Teeter, K. C. (US)
    Tucker, P. K. (US)
    Celkový počet autorů5
    Zdroj.dok.Molecular Biology and Evolution. - : Oxford University Press - ISSN 0737-4038
    Roč. 32, č. 5 (2015), s. 1208-1220
    Poč.str.13 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovahybrid zone ; mouse genome ; speciation
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEPEE2.3.20.0303 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    Institucionální podporaUBO-W - RVO:68081766
    UT WOS000355318400008
    EID SCOPUS84929643654
    DOI10.1093/molbev/msv011
    AnotaceGenomic features such as rate of recombination and differentiation have been suggested to play a role in species divergence. However, the relationship of these phenomena to functional organization of the genome in the context of reproductive isolation remains unexplored. Here, we examine genomic characteristics of the species boundaries between two house mouse subspecies (Mus mus musculus/M. m. domesticus). These taxa form a narrow semi-permeable zone of secondary contact across Central Europe. Due to the incomplete nature of reproductive isolation gene flow in the zone varies across the genome. We present an analysis of genomic differentiation, rate of recombination and functional composition of genes relative to varying amounts of introgression. We assessed introgression using 1316 autosomal SNP markers, previously genotyped in hybrid populations from three transects. We found a significant relationship between amounts of introgression and both genomic differentiation and rate of recombination with genomic regions of reduced introgression associated with higher genomic differentiation and lower rates of recombination, and the opposite for genomic regions of extensive introgression. We also found a striking functional polarization of genes based on where they are expressed in the cell. Regions of elevated introgression exhibit a disproportionate number of genes involved in signal transduction functioning at the cell periphery, among which olfactory receptor genes were found to be the most prominent group. Conversely, genes expressed intracellularly and involved in DNA binding were the most prevalent in regions of reduced introgression. We hypothesize that functional organization of the genome is an important driver of species divergence.
    PracovištěÚstav biologie obratlovců
    KontaktHana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
    Rok sběru2016
Počet záznamů: 1  

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