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A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats
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SYSNO ASEP 0439460 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats Tvůrce(i) Mareš, Pavel (FGU-C) RID, ORCID Zdroj.dok. Journal of Neural Transmission. - : Springer - ISSN 0300-9564
Roč. 121, č. 11 (2014), s. 1329-1336Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. AT - Rakousko Klíč. slova adenosine receptors ; epileptic afterdischarges ; cerebral cortex ; ontogeny ; rat Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP LH11015 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora FGU-C - RVO:67985823 UT WOS 000344353700002 EID SCOPUS 84901522884 DOI 10.1007/s00702-014-1234-y Anotace Endo- as well as exogenous adenosine exhibits anticonvulsant action. Participation of individual types of adenosine receptors was studied in present experiments in immature rats. Cortical epileptic afterdischarges were used as a model in rat pups 12, 18 and 25 days old. CCPA, an agonist of A1 adenosine receptors, decreased markedly duration of afterdischarges whereas DPCPX, an antagonist of A1 receptors, exhibited strong proconvulsant action. Action of either drug was best expressed in 12-day-old rats and it decreased with age. Drugs influencing A2A adenosine receptors (agonist CGS21680 and antagonist ZM241385) did not exhibit systematic effects in our model. Motor phenomena accompanying cortical stimulation or epileptic afterdischarge were never influenced by any of the four drugs studied. A1 adenosine receptors are important in the model of cortical seizures, especially in the youngest group studied Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2015
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