Počet záznamů: 1  

Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP

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    SYSNO ASEP0438420
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAge-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP
    Tvůrce(i) Zavala-Tecuapetla, Cecília (FGU-C)
    Kubová, Hana (FGU-C) RID
    Otáhal, Jakub (FGU-C) RID
    Tsenov, Grygoriy (FGU-C) RID
    Mareš, Pavel (FGU-C) RID
    Zdroj.dok.Pharmacological Reports - ISSN 1734-1140
    Roč. 66, č. 5 (2014), s. 927-930
    Poč.str.4 s.
    Jazyk dok.eng - angličtina
    Země vyd.PL - Polsko
    Klíč. slovaepileptic afterdischarge ; hippocampus ; rat ; ontogeny ; metabotropic glutamate receptor 5
    Vědní obor RIVFH - Neurologie, neurochirurgie, neurovědy
    CEPGA305/09/0846 GA ČR - Grantová agentura ČR
    GBP304/12/G069 GA ČR - Grantová agentura ČR
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000341061600030
    DOI10.1016/j.pharep.2014.02.018
    AnotaceAction of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured.MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals.Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2015