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Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis
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SYSNO ASEP 0437495 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis Tvůrce(i) Hrubý, Martin (UMCH-V) RID, ORCID Zdroj.dok. Military Medical Science Letters. - : Univerzita obrany - ISSN 0372-7025
Roč. 83, č. 4 (2014), s. 178-182Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova Ebola virus ; cathepsin ; polymer Vědní obor RIV EE - Mikrobiologie, virologie CEP 7F14009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA13-08336S GA ČR - Grantová agentura ČR Institucionální podpora UMCH-V - RVO:61389013 Anotace Polymer drug delivery systems were during last few decades proven to be efficient potential therapeutics for cancer treatment, especilly for the treatment of solid tumors, where they may take advantage of the Enhanced Permeability and Retention (EPR) effect for tumor-specific passive accumulation. Controlled release of anticancer drugs in cancer cells may be triggered by. e.g., cathepsin B activation after endocytosis. Endosomal proteases, especially cathepsins B and L, are known to be one of the key factors influencing some viral infections. For instance Ebola virus requires partial proteolysis of its surface glycoprotein for efficient endosome escape within its life cycle. We hypothesize that polymeric cathepsin B and L inhibitors may utilize advantages of polymer delivery systems for more effective treatment of viral infections with cathepsin inhibitors reducing systemic toxicity and increasing efficacy by targeted delivery of these inhibitors. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2015 Elektronická adresa http://mmsl.cz/viCMS/soubory/pdf/MMSL_2014_4_5_WWW.pdf
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