Počet záznamů: 1
Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters
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SYSNO ASEP 0435165 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters Tvůrce(i) Hofer, Michal (BFU-R) RID, ORCID
Pospíšil, Milan (BFU-R)
Dušek, L. (CZ)
Hoferová, Zuzana (BFU-R) RID
Komůrková, Denisa (BFU-R) RID, ORCIDCelkový počet autorů 5 Zdroj.dok. Purinergic Signalling - ISSN 1573-9538
Roč. 10, č. 3 (2014), s. 509-514Poč.str. 6 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Adenosine A(3) receptor ; Adenosine A(3) receptor knockout mice ; Hematopoiesis Vědní obor RIV BO - Biofyzika CEP GAP303/11/0128 GA ČR - Grantová agentura ČR Institucionální podpora BFU-R - RVO:68081707 UT WOS 000341772500010 DOI 10.1007/s11302-014-9412-9 Anotace The role of the adenosine A(3) receptor in hematopoiesis was studied using adenosine A(3) receptor knockout (A(3)AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A(3)AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A(3)AR KO mice and WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A(3)AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A(3) receptor in the hematopoietic system. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2015
Počet záznamů: 1