Počet záznamů: 1
Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics
- 1.
SYSNO ASEP 0434619 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics Tvůrce(i) Gusareva, Elena (UMG-J)
Kurey, Irina (UMG-J)
Grekov, Igor (UMG-J) RID
Lipoldová, Marie (UMG-J) RIDZdroj.dok. Biological Reviews. - : Wiley - ISSN 1464-7931
Roč. 89, č. 2 (2014), s. 375-405Poč.str. 31 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Genetic control of complex diseases ; Immunoglobulin E ; Epistasis Vědní obor RIV EB - Genetika a molekulární biologie CEP GA310/08/1697 GA ČR - Grantová agentura ČR LH12049 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMG-J - RVO:68378050 UT WOS 000334182600007 DOI 10.1111/brv.12059 Anotace Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2015
Počet záznamů: 1