Počet záznamů: 1
Age-Related Differences in NMDA Receptor Subunits of Prenatally Methamphetamine-Exposed Male Rats
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SYSNO ASEP 0430525 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Age-Related Differences in NMDA Receptor Subunits of Prenatally Methamphetamine-Exposed Male Rats Tvůrce(i) Vrajová, M. (CZ)
Schutová, B. (CZ)
Klaschka, Jan (UIVT-O) RID, SAI, ORCID
Štěpánková, H. (CZ)
Řípová, D. (CZ)
Šlamberová, R. (CZ)Zdroj.dok. Neurochemical Research. - : Springer - ISSN 0364-3190
Roč. 39, č. 11 (2014), s. 2040-2046Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova methamphetamine ; in-utero ; NMDA receptor subunits ; hippocampus Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Institucionální podpora UIVT-O - RVO:67985807 UT WOS 000343293000003 EID SCOPUS 84910107229 DOI 10.1007/s11064-014-1381-4 Anotace There is accumulating evidence that methamphetamine (MA) is a widely abused drug popular among pregnant women. MA exposure is associated with changes in the function of neurotransmitter systems, namely the dopaminergic, serotonergic and glutamatergic systems. Since N-methyl-d-aspartate receptors (NMDA) are affected by MA-induced glutamate release, we assessed the expression of NMDAR subunits (NR1, NR2A, and NR2B) and postsynaptic density protein 95 (PSD-95), which is connected with NMDAR. We measured the expression of these proteins in adolescent (30 days old) and adult (60 days old) rat males exposed to MA during the entire prenatal period and compared them with the same parameters in age matched saline-exposed rats. There was a significant increase in the NR1 and NR2B subunits in the hippocampus of adult males, but not in adolescent males. We identified a significant change in adult MA-induced rats when compared to adult controls for NR2A and NR2B, while in adolescent MA rats this change was close to the boundary of significance. In summary, our study suggests that prenatal MA exposure is connected with changes in NMDAR subunit expression in adult rats but not in adolescent rats. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2015
Počet záznamů: 1