Počet záznamů: 1
Theoretical models of DNA flexibility
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SYSNO ASEP 0428591 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Theoretical models of DNA flexibility Tvůrce(i) Dršata, Tomáš (UOCHB-X) RID
Lankaš, Filip (UOCHB-X) RIDCelkový počet autorů 2 Zdroj.dok. Wiley Interdisciplinary Reviews - Computational Molecular Science - ISSN 1759-0876
Roč. 3, č. 4 (2013), s. 355-363Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova molecular dynamics simulations ; base pair level ; indirect readout Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000334577900003 EID SCOPUS 84879084489 DOI 10.1002/wcms.1144 Anotace DNA sequence-dependent three-dimensional structure and mechanical deformability play a large role in biological processes such as protein-DNA interactions, nucleosome positioning, promoter identification, and drug-DNA recognition. On the important scale of 10-100 base pairs, models where DNA bases are represented by interacting rigid bodies have proved useful. We focus on a recently proposed rigid base model with nonlocal, harmonic interaction energy. We discuss the choice of internal coordinates and a method to obtain model parameters from coordinate fluctuations. Parameter transformation upon change of reference strand, coordinate constraints, and models with reduced number of degrees of freedom are described. Relation to traditional local harmonic models is clarified. We outline recent attempts to include anharmonic effects. A rigid base model of a DNA oligomer containing A-tract is presented as an example. Perspectives of model development and application are discussed. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2015
Počet záznamů: 1