Počet záznamů: 1  

beta-Arrestin Interacts with the Beta/Gamma Subunits of Trimeric G-Proteins and Dishevelled in the Wnt/Ca2+ Pathway in Xenopus Gastrulation

  1. 1.
    SYSNO ASEP0427975
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    Názevbeta-Arrestin Interacts with the Beta/Gamma Subunits of Trimeric G-Proteins and Dishevelled in the Wnt/Ca2+ Pathway in Xenopus Gastrulation
    Tvůrce(i) Seitz, K. (DE)
    Dursch, V. (DE)
    Harnoš, J. (CZ)
    Bryja, Vítězslav (BFU-R) RID
    Gentzel, M. (DE)
    Schambony, A. (DE)
    Celkový počet autorů6
    Zdroj.dok.PLoS ONE
    Roč. 9, č. 1 (2014)
    Poč.str.11 s.
    Forma vydáníTištěná - P
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaCONVERGENT EXTENSION MOVEMENTS ; WNT SIGNALING PATHWAYS ; WNT/BETA-CATENIN
    Vědní obor RIVBO - Biofyzika
    CEPGC204/09/J030 GA ČR - Grantová agentura ČR
    Institucionální podporaBFU-R - RVO:68081707
    UT WOS000330570000107
    DOI10.1371/journal.pone.0087132
    Anotacebeta-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and beta-Catenin independent signaling cascades including the Wnt/Planar Cell Polarity and the Wnt/Ca2+ cascades. Wnt/Planar Cell Polarity and Wnt/Ca2+ pathways share common effector proteins, including the Wnt ligand, Frizzled receptors and Dishevelled, with each other and with additional branches of Wnt signaling. Along with the aforementioned proteins, beta-Arrestin has been identified as an essential effector protein in the Wnt/beta-Catenin and the Wnt/Planar Cell Polarity pathway. Our results demonstrate that beta-Arrestin is required in the Wnt/Ca2+ signaling cascade upstream of Protein Kinase C (PKC) and Ca2+/Calmodulin-dependent Protein Kinase II (CamKII). We have further characterized the role of beta-Arrestin in this branch of non-canonical Wnt signaling by knock-down and rescue experiments in Xenopus embryo explants and analyzed protein-protein interactions in 293T cells.
    PracovištěBiofyzikální ústav
    KontaktJana Poláková, polakova@ibp.cz, Tel.: 541 517 244
    Rok sběru2015