Počet záznamů: 1

Comprehensive portrait of cholesterol containing oxidized membrane

SYSNO ASEP	0427792
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Comprehensive portrait of cholesterol containing oxidized membrane
Tvůrce(i)	Štefl, Martin (UFCH-W) Šachl, Radek (UFCH-W)_{RID, ORCID} Olžyńska, Agnieszka (UFCH-W)_RID Amaro, Mariana (UFCH-W)_{RID, ORCID} Savchenko, Dariia (FZU-D)_{RID, ORCID} Deyneka, Alexander (FZU-D) Hermetter, A. (AT) Cwiklik, Lukasz (UFCH-W)_{RID, ORCID} Humpolíčková, Jana (UFCH-W)_RID Hof, Martin (UFCH-W)_{RID, ORCID}
Zdroj.dok.	Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736 Roč. 1838, č. 7 (2014), s. 1769-1776
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	oxidized lipids ; lateral diffusion ; molecular dynamics simulations
Vědní obor RIV	CF - Fyzikální chemie a teoretická chemie
CEP	GBP208/12/G016 GA ČR - Grantová agentura ČR
	LH13259 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	UFCH-W - RVO:61388955 ; FZU-D - RVO:68378271
UT WOS	000336695300009
EID SCOPUS	84899037032
DOI	10.1016/j.bbamem.2014.02.006
Anotace	Biologicalmembranes are under significant oxidative stress caused by reactive oxygen species mostly originating during cellular respiration. Double bonds of the unsaturated lipids are most prone to oxidation,which might lead to shortening of the oxidized chain and inserting of terminal either aldehyde or carboxylic group. Structural rearrangement of oxidized lipids, addressed already, is mainly associated with looping back of the hydrophilic terminal group. This contribution utilizing dual-focus fluorescence correlation spectroscopy and electron paramagnetic resonance as well as atomistic molecular dynamics simulations focuses on the overall changes of the membrane structural and dynamical properties once it becomes oxidized. Particularly, attention is paid to cholesterol rearrangement in the oxidized membrane revealing its preferable interaction with carbonyls of the oxidized chains. In this view cholesterol seems to have a tendency to repair, rather than condense, the bilayer.
Pracoviště	Ústav fyzikální chemie J.Heyrovského
Kontakt	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Rok sběru	2015

Počet záznamů: 1