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Biotransformation of Silybin and its Congeners
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SYSNO ASEP 0423434 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biotransformation of Silybin and its Congeners Tvůrce(i) Křen, Vladimír (MBU-M) RID, ORCID
Marhol, Petr (MBU-M) RID
Purchartová, Kateřina (MBU-M) RID
Gabrielová, E. (CZ)
Modrianský, M. (CZ)Zdroj.dok. Current Drug Metabolism. - : Bentham Science Publishers - ISSN 1389-2002
Roč. 14, č. 10 (2013), s. 1009-1021Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. AE - Spojené arabské emiráty Klíč. slova Biotransformation ; cytochrome P450 ; diastereoisomers Vědní obor RIV CE - Biochemie CEP GAP301/11/0662 GA ČR - Grantová agentura ČR LD11051 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora MBU-M - RVO:61388971 UT WOS 000329033900001 Anotace Silybin and its congeners belong to a group of flavonolignans with strong biological activities. These compounds are potentially applicable in human medicine, e.g. due to their cytoprotective activity. As a part of herbal preparations available on the open market, they face the risk of potential negative drug-drug interactions. This review aims to evaluate current knowledge on the metabolism of these compounds by biotransformation enzymes, interactions with other drugs, their pharmacokinetics, and bioavailability. While silybin and its derivatives interact with cytochrome P450s, only metabolism of silybin by cytochrome P450 2C8 poses a risk of adverse effects. The main biotransformation route of silybin and derivatives was identified as conjugation, which is stereospecific in case of silybin. Studies of the metabolism, pharmacokinetics, potentional drug - drug interactions and increasing bioavailability of these flavonolignans play an important facet of possible therapeutical use of these compounds. The goal of our review is to aid future developments in the area of silybin research Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2014 Elektronická adresa http://www.ncbi.nlm.nih.gov/pubmed/24261705
Počet záznamů: 1