Počet záznamů: 1
Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microDNA
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SYSNO ASEP 0422599 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microDNA Tvůrce(i) Vilmos, P. (HU)
Bujna, Á. (HU)
Szuperák, M. (AU)
Havelda, Z. (HU)
Várallyay, É. (HU)
Szabad, J. (HU)
Kučerová, Lucie (BC-A) RID, ORCID
Somogyi, K. (DE)
Kristó, I. (HU)
Lukácsovich, T. (US)
Jankovics, F. (HU)
Henn, L. (HU)
Erdélyi, M. (HU)Celkový počet autorů 13 Zdroj.dok. Genetics. - : Genetics Society of America - ISSN 0016-6731
Roč. 195, č. 2 (2013), s. 469-480Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Drosophila melanogaster Vědní obor RIV ED - Fyziologie Institucionální podpora BC-A - RVO:60077344 UT WOS 000325286200016 EID SCOPUS 84884946495 DOI 10.1534/genetics.113.153585 Anotace The first microRNAs were discovered some 20 years ago, but only a small fraction of the microRNA-encoding genes have been described in detail yet. Here we report the molecular analysis of a computationally predicted Drosophila melanogaster microRNA gene, mir-282. We show that the mir-282 gene is the source of a 4.9-kb-long primary transcript with a 5' cap and a 3'-poly(A) sequence and a mature microRNA of similar to 25 bp. Our data strongly suggest the existence of an independent mir-282 gene conserved in holometabolic insects. We give evidence that the mir-282 locus encodes a functional transcript that influences viability, longevity, and egg production in Drosophila. We identify the nervous system-specific adenylate cyclase (rutabaga) as a target of miR-282 and assume that one of the main functions of mir-282 is the regulation of adenylate cyclase activity in the nervous system during metamorphosis. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2014
Počet záznamů: 1