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Mitochondrial complex II, a novel target for anti-cancer agents
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SYSNO ASEP 0420969 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mitochondrial complex II, a novel target for anti-cancer agents Tvůrce(i) Klučková, Katarína (BTO-N) RID
Bezawork-Geleta, A. (AU)
Rohlena, Jakub (BTO-N) RID, ORCID
Dong, L. (AU)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Biochimica Et Biophysica Acta-Bioenergetics. - : Elsevier - ISSN 0005-2728
Roč. 1827, č. 5 (2013), s. 552-564Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Mitochondrion ; Complex II ; Anti-cancer agent Vědní obor RIV EB - Genetika a molekulární biologie CEP GAP301/10/1937 GA ČR - Grantová agentura ČR GAP301/12/1851 GA ČR - Grantová agentura ČR CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000317795100003 DOI 10.1016/j.bbabio.2012.10.015 Anotace With the arrival of the third millennium, in spite of unprecedented progress in molecular medicine, cancer remains as untamed as ever. The complexity of tumours, dictating the potential response of cancer cells to anti-cancer agents, has been recently highlighted in a landmark paper by Weinberg and Hanahan on hallmarks of cancer [1]. Together with the recently published papers on the complexity of tumours in patients and even within the same tumour (see below), the cure for this pathology seems to be an elusive goal. Indisputably, the strategy ought to be changed, searching for targets that are generally invariant across the landscape of neoplastic diseases. One such target appears to be the mitochondrial complex II (CII) of the electron transfer chain, a recent focus of research. We document and highlight this particularly intriguing target in this review paper and give examples of drugs that use CII as their molecular target. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease. (C) 2012 Elsevier B.V. All rights reserved. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2014
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