Počet záznamů: 1
Interaction of the tick immune system with transmitted pathogens
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SYSNO ASEP 0396807 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Interaction of the tick immune system with transmitted pathogens Tvůrce(i) Hajdušek, Ondřej (BC-A) RID, ORCID
Šíma, Radek (BC-A) RID, ORCID
Ayllón, N. (ES)
Jalovecká, M. (CZ)
Pernes, J. (CZ)
de la Fuente, J. (ES)
Kopáček, Petr (BC-A) RID, ORCIDZdroj.dok. Frontiers in Cellular and Infection Microbiology. - : Frontiers Media - ISSN 2235-2988
Roč. 3, Jul 2013 (2013), a26Poč.str. 15 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova Anaplasma ; Babesia ; Borrelia ; antimicrobial peptides ; innate immunity ; phagocytosis ; tick ; tick-borne diseases Vědní obor RIV EC - Imunologie CEP GAP506/10/2136 GA ČR - Grantová agentura ČR GA13-11043S GA ČR - Grantová agentura ČR GP13-27630P GA ČR - Grantová agentura ČR GP13-12816P GA ČR - Grantová agentura ČR EE2.3.30.0032 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora BC-A - RVO:60077344 UT WOS 000324649500003 DOI 10.3389/fcimb.2013.00026 Anotace Ticks are hematophagous arachnids transmitting a wide variety of pathogens including viruses, bacteria, and protozoans to their vertebrate hosts. The tick vector competence has to be intimately linked to the ability of transmitted pathogens to evade tick defense mechanisms encountered on their route through the tick body comprising midgut, hemolymph, salivary glands or ovaries. Tick innate immunity is, like in other invertebrates, based on an orchestrated action of humoral and cellular immune responses. The direct antimicrobial defense in ticks is accomplished by a variety of small molecules such as defensins, lysozymes or by tick-specific antimicrobial compounds such as microplusin/hebraein or 5.3-kDa family proteins. Phagocytosis of the invading microbes by tick hemocytes is likely mediated by the primordial complement-like system composed of thioester-containing proteins, fibrinogen-related lectins and convertase-like factors. Moreover, an important role in survival of the ingested microbes seems to be played by host proteins and redox balance maintenance in the tick midgut. Here, we summarize recent knowledge about the major components of tick immune system and focus on their interaction with the relevant tick-transmitted pathogens, represented by spirochetes (Borrelia), rickettsiae (Anaplasma), and protozoans (Babesia). Availability of the tick genomic database and feasibility of functional genomics based on RNA interference greatly contribute to the understanding of molecular and cellular interplay at the tick-pathogen interface and may provide new targets for blocking the transmission of tick pathogens. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2014
Počet záznamů: 1