Počet záznamů: 1  

Interaction of the tick immune system with transmitted pathogens

  1. 1.
    SYSNO ASEP0396807
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevInteraction of the tick immune system with transmitted pathogens
    Tvůrce(i) Hajdušek, Ondřej (BC-A) RID, ORCID
    Šíma, Radek (BC-A) RID, ORCID
    Ayllón, N. (ES)
    Jalovecká, M. (CZ)
    Pernes, J. (CZ)
    de la Fuente, J. (ES)
    Kopáček, Petr (BC-A) RID, ORCID
    Zdroj.dok.Frontiers in Cellular and Infection Microbiology. - : Frontiers Media - ISSN 2235-2988
    Roč. 3, Jul 2013 (2013), a26
    Poč.str.15 s.
    Forma vydáníOnline - E
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovaAnaplasma ; Babesia ; Borrelia ; antimicrobial peptides ; innate immunity ; phagocytosis ; tick ; tick-borne diseases
    Vědní obor RIVEC - Imunologie
    CEPGAP506/10/2136 GA ČR - Grantová agentura ČR
    GA13-11043S GA ČR - Grantová agentura ČR
    GP13-27630P GA ČR - Grantová agentura ČR
    GP13-12816P GA ČR - Grantová agentura ČR
    EE2.3.30.0032 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    Institucionální podporaBC-A - RVO:60077344
    UT WOS000324649500003
    DOI10.3389/fcimb.2013.00026
    AnotaceTicks are hematophagous arachnids transmitting a wide variety of pathogens including viruses, bacteria, and protozoans to their vertebrate hosts. The tick vector competence has to be intimately linked to the ability of transmitted pathogens to evade tick defense mechanisms encountered on their route through the tick body comprising midgut, hemolymph, salivary glands or ovaries. Tick innate immunity is, like in other invertebrates, based on an orchestrated action of humoral and cellular immune responses. The direct antimicrobial defense in ticks is accomplished by a variety of small molecules such as defensins, lysozymes or by tick-specific antimicrobial compounds such as microplusin/hebraein or 5.3-kDa family proteins. Phagocytosis of the invading microbes by tick hemocytes is likely mediated by the primordial complement-like system composed of thioester-containing proteins, fibrinogen-related lectins and convertase-like factors. Moreover, an important role in survival of the ingested microbes seems to be played by host proteins and redox balance maintenance in the tick midgut. Here, we summarize recent knowledge about the major components of tick immune system and focus on their interaction with the relevant tick-transmitted pathogens, represented by spirochetes (Borrelia), rickettsiae (Anaplasma), and protozoans (Babesia). Availability of the tick genomic database and feasibility of functional genomics based on RNA interference greatly contribute to the understanding of molecular and cellular interplay at the tick-pathogen interface and may provide new targets for blocking the transmission of tick pathogens.
    PracovištěBiologické centrum (od r. 2006)
    KontaktDana Hypšová, eje@eje.cz, Tel.: 387 775 214
    Rok sběru2014
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.