Počet záznamů: 1
The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance
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SYSNO ASEP 0396406 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance Tvůrce(i) Chmelař, Jindřich (BC-A)
Chung, K.-J. (DE)
Chavakis, T. (DE)Zdroj.dok. Thrombosis and Haemostasis. - : Georg Thieme Verlag - ISSN 0340-6245
Roč. 109, č. 3 (2013), s. 399-406Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova Obesity ; adipose tissue ; inflammation ; review ; leukocytes Vědní obor RIV EC - Imunologie Institucionální podpora BC-A - RVO:60077344 UT WOS 000316164200007 DOI 10.1160/TH12-09-0703 Anotace Obesity is characterised by a chronic state of low-grade inflammation in different tissues including the vasculature. There is a causal link between adipose tissue (AT) inflammation and obesity-related metabolic complications, such as the development of insulin resistance and subsequently of type 2 diabetes. Intense efforts in the recent years have aimed at dissecting the pathophysiology of AT inflammation. The role of both innate and adaptive immune cells, such as macrophages or cytotoxic T cells in AT inflammation has been demonstrated. Besides these cells, more leukocyte subpopulations have been recently implicated in obesity, including neutrophils and eosinophils, mast cells, natural killer cells or dendritic cells. The involvement of multiple leukocyte subpopulations underlines the complexity of obesity-associated AT inflammation. In this review, we discuss the role of innate immune cells in AT inflammation, obesity and related metabolic disorders. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2014
Počet záznamů: 1