Počet záznamů: 1
Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster
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SYSNO ASEP 0394182 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster Tvůrce(i) Kiss, B. (HU)
Szlanka, T. (HU)
Zvara, Á. (HU)
Žurovec, Michal (BC-A) RID, ORCID
Šerý, Michal (BC-A) ORCID
Kakaš, Štefan (BC-A)
Ramasz, B. (HU)
Hegedűs, Z. (HU)
Lukacsovich, T. (US)
Puskás, L. (HU)
Fónagy, A. (HU)
Kiss, I. (HU)Celkový počet autorů 12 Zdroj.dok. General and Comparative Endocrinology. - : Elsevier - ISSN 0016-6480
Roč. 191, SEP 15 (2013), s. 137-145Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Drosophila melanogaster ; FMRF-related peptides ; G protein-coupled receptors Vědní obor RIV EB - Genetika a molekulární biologie Institucionální podpora BC-A - RVO:60077344 UT WOS 000323870400015 EID SCOPUS 84880386491 DOI 10.1016/j.ygcen.2013.05.023 Anotace Drosophila FMRF-related neuropeptides are functionally unrelated peptides targeting different organs, with different effective thresholds, time-course and expression patterns. They were all suggested to have an effect on the locomotor activity of Drosophila adults. We prepared RNAi knockdowns of the peptides and their specific receptor genes as well as ablated FMRF-positive neurons by inducing apoptosis using the reaper (rpr) gene expression. We show that RNAi silencing of the FaRP and FaRP-receptor genes effectively decreased the startle-induced locomotor activity of flies. Consistantly, the ablation of FMRF-positive neurons by the RS8-Gal4 and/or RS17-Gal4 drivers also significantly decreased fly locomotion. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2014 Elektronická adresa http://www.sciencedirect.com/science/article/pii/S0016648013002621
Počet záznamů: 1