Počet záznamů: 1
Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats
- 1.
SYSNO ASEP 0390670 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats Tvůrce(i) Vaněčková, Ivana (FGU-C) RID, ORCID
Kujal, P. (CZ)
Husková, Z. (CZ)
Vaňourková, Z. (CZ)
Vernerová, Z. (CZ)
Čertíková - Chábová, V. (CZ)
Škaroupková, P. (CZ)
Kramer, H. J. (DE)
Tesař, V. (CZ)
Červenka, L. (CZ)Zdroj.dok. Kidney & Blood Pressure Research. - : Karger - ISSN 1420-4096
Roč. 35, č. 5 (2012), s. 382-392Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova 5/6 nephrectomy ; Endothelin receptor type A ; AT1 receptor blocker ; end-organ damage ; hypertension Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000305594600011 DOI 10.1159/000336823 Anotace The additive effect of endothelin-1 blockade to renin-angiotensin blockade was evaluated in rats with ablation nephrectomy. While RAS blockade normalized blood pressure (BP), improved survival, decreased cardiac hypertrophy and proteinuria as well as tissue angiotensin II and ET-1 levels, ETA receptor blockade only partially improved survival rate, reduced BP, attenuated the development of cardiac hypertrophy and transiently reduced proteinuria. No additive cardio- and renoprotective effects of ETA and RAS blockade were noted at the end of the study suggesting that the RAS system is the main target for antihypertensive treatment in models with inappropriately activated RAS Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2013
Počet záznamů: 1