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The coiled coil motif in polymer drug delivery systems
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SYSNO ASEP 0388063 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The coiled coil motif in polymer drug delivery systems Tvůrce(i) Pechar, Michal (UMCH-V) RID, ORCID
Pola, Robert (UMCH-V) RID, ORCIDZdroj.dok. Biotechnology Advances. - : Elsevier - ISSN 0734-9750
Roč. 31, č. 1 (2013), s. 90-96Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova coiled coil ; hydrophilic polymer ; recombinant protein Vědní obor RIV CD - Makromolekulární chemie CEP GA203/08/0543 GA ČR - Grantová agentura ČR 1M0505 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000315761200009 DOI 10.1016/j.biotechadv.2012.01.003 Anotace The coiled coil is a superhelical structural protein motif that has been thoroughly investigated in recent years. Because of the relatively well-understood principles that determine the properties of coiled coil peptides and proteins, macromolecular systems containing the coiled coil motif have been suggested for various applications. This short review focuses on hybrid polymer coiled coil systems designed for drug delivery purposes. After a short introduction, the most important features of the coiled coils (stability, association number, oligomerization selectivity and orientation of helices) are described, and the factors influencing these characteristics are discussed. Several examples of the most interesting biomedical applications of the polymer-coiled coil systems (according to the authors' opinion) are presented. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2013
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