Počet záznamů: 1

Genetics of host response to Leishmania tropica in mice - different control of skin pathology, chemokine reaction, and iInvasion into spleen and liver

SYSNO ASEP	0381628
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Genetics of host response to Leishmania tropica in mice - different control of skin pathology, chemokine reaction, and iInvasion into spleen and liver
Tvůrce(i)	Kobets, Tetyana (UMG-J)_RID Havelková, Helena (UMG-J) Grekov, Igor (UMG-J)_RID Volkova, Valeriya (UMG-J) Vojtíšková, Jarmila (UMG-J) Slapničková, Martina (UMG-J) Kurey, Irina (UMG-J) Sohrabi, Yahya (UMG-J) Svobodová, M. (CZ) Demant, P. (US) Lipoldová, Marie (UMG-J)_RID
Zdroj.dok.	PLoS Neglected Tropical Diseases. - : Public Library of Science - ISSN 1935-2735 Roč. 6, č. 6 (2012), e1667
Poč.str.	12 s.
Forma vydání	Online - E
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	leishmaniasis ; Leishmania tropica ; Leishmania major
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GA310/08/1697 GA ČR - Grantová agentura ČR
	GD310/08/H077 GA ČR - Grantová agentura ČR
	LC06009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	UMG-J - RVO:68378050
UT WOS	000305945300011
DOI	10.1371/journal.pntd.0001667
Anotace	Background: Leishmaniasis is a disease caused by protozoan parasites of genus Leishmania. The frequent involvement of Leishmania tropica in human leishmaniasis has been recognized only recently. Similarly as L. major, L. tropica causes cutaneous leishmaniasis in humans, but can also visceralize and cause systemic illness. The relationship between the host genotype and disease manifestations is poorly understood because there were no suitable animal models. Methods: We studied susceptibility to L. tropica, using BALB/c-c-STS/A (CcS/Dem) recombinant congenic (RC) strains, which differ greatly in susceptibility to L. major. Mice were infected with L. tropica and skin lesions, cytokine and chemokine levels in serum, and parasite numbers in organs were measured. Principal Findings: Females of BALB/c and several RC strains developed skin lesions. In some strains parasites visceralized and were detected in spleen and liver. Importantly, the strain distribution pattern of symptoms caused by L. tropica was different from that observed after L. major infection. Moreover, sex differently influenced infection with L. tropica and L. major. L. major-infected males exhibited either higher or similar skin pathology as females, whereas L. tropica-infected females were more susceptible than males. The majority of L. tropica-infected strains exhibited increased levels of chemokines CCL2, CCL3 and CCL5. CcS-16 females, which developed the largest lesions, exhibited a unique systemic chemokine reaction, characterized by additional transient early peaks of CCL3 and CCL5, which were not present in CcS-16 males nor in any other strain. Conclusion: Comparison of L. tropica and L. major infections indicates that the strain patterns of response are species-specific, with different sex effects and largely different host susceptibility genes.
Pracoviště	Ústav molekulární genetiky
Kontakt	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Rok sběru	2013

Počet záznamů: 1