Počet záznamů: 1
Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles
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SYSNO ASEP 0380755 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles Tvůrce(i) Staaf, E. (SE)
Brehwens, K. (SE)
Haghdoost, S. (SE)
Nievaart, S. (NL)
Pachnerová Brabcová, Kateřina (UJF-V) RID, ORCID, SAI
Czub, J. (PL)
Braziewicz, J. (PL)
Wojcik, A. (PL)Zdroj.dok. Radiation and Environmental Biophysics - ISSN 0301-634X
Roč. 51, č. 3 (2012), s. 283-293Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova Micronuclei ; LET ; Combined exposure ; Mixed beams ; Alpha particles ; X-rays Vědní obor RIV BO - Biofyzika CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000306694000006 DOI 10.1007/s00411-012-0417-x Anotace The purpose of this study was to analyse the cytogenetic effect of exposing human peripheral blood lymphocytes (PBL) to a mixed beam of alpha particles and X-rays. Whole blood collected from one donor was exposed to different doses of alpha particles (Am-241), X-rays and a combination of both. Micronuclei (MN) in binucleated PBL were scored as the endpoint. Moreover, the size of MN was measured. The results show that exposure of PBL to a mixed beam of high and low linear energy transfer radiation led to significantly higher than expected frequencies of MN. The measurement of MN size did not reveal any differences between the effect of alpha particles and mixed beam. In conclusion, a combined exposure of PBL to alpha particles and X-rays leads to a synergistic effect as measured by the frequency of MN. From the analysis of MN distributions, we conclude that the increase was due to an impaired repair of X-ray-induced DNA damage. Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2013
Počet záznamů: 1