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Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts
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SYSNO ASEP 0380633 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts Tvůrce(i) Neckář, Jan (FGU-C) RID, ORCID
Boudíková, Adéla (FGU-C)
Mandíková, Petra (FGU-C)
Štěrba, M. (CZ)
Popelová, O. (CZ)
Mikšík, Ivan (FGU-C) RID, ORCID, SAI
Dabrowská, L. (CZ)
Mráz, J. (CZ)
Geršl, V. (CZ)
Kolář, František (FGU-C) RID, ORCID, SAIZdroj.dok. Canadian Journal of Physiology and Pharmacology. - : Canadian Science Publishing - ISSN 0008-4212
Roč. 90, č. 9 (2012), s. 1303-1310Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. CA - Kanada Klíč. slova heart ; dexrazoxane ; ischaemia ; reperfusion ; infarct size ; arrhythmias ; cardioprotection ; reactive oxygen species Vědní obor RIV FR - Farmakologie a lékárnická chemie CEP IAAX01110901 GA AV ČR - Akademie věd GA305/09/0416 GA ČR - Grantová agentura ČR CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000308152200017 DOI 10.1139/y2012-096 Anotace The aim of our study was to find out whether dexrazoxane (DEX) treatment reduces myocardial infarct size and arrhythmias induced by regional I/R in open-chest rats and in isolated perfused hearts, and to find out its most effective dose. Our results showed that DEX in the single dose of 150 mg•kg–1 effectively suppressed ventricular arrhythmias in isolated hearts subjected to acute I/R, but it was insufficient to reduce arrhythmias in open-chest animals, and only the highest dose of DEX (450 mg•kg–1) decreased myocardial infarct size. The protective effects of DEX were not accompanied by decreases of oxidative stress markers in the myocardium, suggesting that other protective mechanism(s) than limitation of ROS formation might play a role Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2013
Počet záznamů: 1