Počet záznamů: 1
Polymorphisms in miRNA binding sites of nucleotide excision repair genes and colorectal cancer risk
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SYSNO ASEP 0379749 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polymorphisms in miRNA binding sites of nucleotide excision repair genes and colorectal cancer risk Tvůrce(i) Naccarati, Alessio (UEM-P)
Pardini, Barbara (UEM-P)
Landi, S. (IT)
Landi, D. (IT)
Slyšková, Jana (UEM-P) RID
Novotný, J. (CZ)
Levý, M. (CZ)
Poláková, Veronika (UEM-P) RID
Lipská, L. (CZ)
Vodička, Pavel (UEM-P) RIDZdroj.dok. Carcinogenesis. - : Oxford University Press - ISSN 0143-3334
Roč. 33, č. 7 (2012), s. 1346-1351Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova DNA repair ; polymorphisms ; miRNA binding sites Vědní obor RIV EB - Genetika a molekulární biologie CEP GAP304/10/1286 GA ČR - Grantová agentura ČR GP305/09/P194 GA ČR - Grantová agentura ČR CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000306925600013 EID SCOPUS 84865187699 DOI 10.1093/carcin/bgs172 Anotace Regulation of and coordination between DNA repair genes is fundamental for maintaining genome stability, and post-transcriptional gene regulation by microRNAs is of particular relevance. In this context, the presence of single nucleotide polymorphisms (SNPs) within the 3´-untranslated regions of target DNA repair genes could alter the binding with specific miRNAs,modulating gene expression and affecting cancer susceptibility. In this study, we investigated the role of genetic variations in miRNA-binding sites of nucleotide excision repair (NER) genes in association with colorectal cancer (CRC) risk. We tested those SNPs based on 28 NER genes in 1098 colorectal cancer cases and 1469 healthy controls from the Czech Republic. Rs7356 in RPA2 and rs4596 in GTF2H1 were associated with colorectal cancer risk. After stratification for tumor location, the association of both SNPs was significant only for rectal cancer (rs7356: OR 1.52, 95% CI 1.02–2.26, P = 0.04 and rs4596: OR 0.69, 95% CI 0.50–0.94, P = 0.02; results not adjusted for multiple testing). Variation in miRNA target binding sites in the 3´-untranslated region of NER genes may be important for modulating CRC risk, with a different relevance according to tumor location. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2013
Počet záznamů: 1