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Cytoskeleton in mast cell signaling
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SYSNO ASEP 0378914 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Cytoskeleton in mast cell signaling Tvůrce(i) Dráber, Pavel (UMG-J) RID, ORCID
Sulimenko, Vadym (UMG-J) RID, ORCID
Dráberová, Eduarda (UMG-J) RID, ORCIDZdroj.dok. Frontiers in Immunology. - : Frontiers Media - ISSN 1664-3224
Roč. 3, May (2012), s. 130Poč.str. 18 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova cytoskeleton ; mast cell activation ; signal transduction Vědní obor RIV EB - Genetika a molekulární biologie CEP GAP302/10/1701 GA ČR - Grantová agentura ČR GPP302/11/P709 GA ČR - Grantová agentura ČR GAP302/12/1673 GA ČR - Grantová agentura ČR CEZ AV0Z50520514 - UMG-J (2005-2011) DOI 10.3389/fimmu.2012.00130 Anotace This review article presents a critical survey of current knowledge on the role of cytokeleton in mast cell signaling. Mast cell activation mediated by the high affinity receptor for IgE (FcεRI) is a key event in allergic response and inflammation. Activation of various signaling pathways results in changes in cell morphology, adhesion to substrate, exocytosis, and migration. Reorganization of cytoskeleton is pivotal in all these processes. Highly dynamic microtubules formed by αβ-tubulin dimers as well as microfilaments build up from polymerized actin are affected in activated cells by kinases/phosphatases, Rho GTPases and changes in concentration of cytosolic Ca2+. The dynamic nature of microtubules and microfilaments in activated cells also depends on many associated/regulatory proteins. In this review, we have summarized recent developments in the biology of cytoskeleton and the role of signaling pathways in the course of mast cell activation. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2013
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