Počet záznamů: 1

Light scattering evidence of selective protein fouling on biocompatible block copolymer micelles

SYSNO ASEP	0378727
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Light scattering evidence of selective protein fouling on biocompatible block copolymer micelles
Tvůrce(i)	Giacomelli, F. C. (BR) Štěpánek, Petr (UMCH-V)_{RID, ORCID} Schmidt, V. (BR) Jäger, Eliezer (UMCH-V)_{ORCID, RID} Jäger, Alessandro (UMCH-V)_{RID, ORCID} Giacomelli, C. (BR)
Zdroj.dok.	Nanoscale. - : Royal Society of Chemistry - ISSN 2040-3364 Roč. 4, č. 15 (2012), s. 4504-4514
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	copolymer micelles ; protein fouling ; light scattering
Vědní obor RIV	CF - Fyzikální chemie a teoretická chemie
CEP	GAP208/10/1600 GA ČR - Grantová agentura ČR
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000306324000027
DOI	10.1039/c2nr30623a
Anotace	Selective protein fouling on block copolymer micelles with well-known potential for tumour-targeting drug delivery was evidenced by using dynamic light scattering measurements. The stability and interaction of block copolymer micelles with model proteins (BSA, IgG, lysozyme and CytC) is reported for systems featuring a hydrophobic (poly[2-(diisopropylamino)-ethyl methacrylate]) (PDPA) core and hydrophilic coronas comprising poly(ethylene oxide)/poly(glycerol monomethacrylate) (PEOb-PG2MA) or poly[2-(methacryloyloxy)ethyl phosphorylcholine] (PMPC). The results revealed that protein size and hydrophilic chain density play important roles in the observed interactions. The successful protein-repellent characteristic of these nanoparticles is attributed to a high hydrophilic surface chain density (>0.1 chains per nm2) and to the length of the hydrophilic chains.
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2013

Počet záznamů: 1