Počet záznamů: 1  

Locations and Reorientations of Multi-Ring-Fused 2-Pyridones in Ganglioside G(M1) Micelles

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    SYSNO ASEP0377559
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevLocations and Reorientations of Multi-Ring-Fused 2-Pyridones in Ganglioside G(M1) Micelles
    Tvůrce(i) Šachl, Radek (UFCH-W) RID
    Rosenbaum, E. (SE)
    Sellstedt, M. (SE)
    Almqvist, F. (SE)
    Johansson, L. B. A. (SE)
    Zdroj.dok.Langmuir. - : AMER CHEMICAL SOC - ISSN 0743-7463
    Roč. 27, č. 5 (2011), s. 1662-1667
    Poč.str.6 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovadirect energy transfer ; fluorescent probe ; polymer mycelles
    Vědní obor RIVCF - Fyzikální chemie a teoretická chemie
    CEPGAP208/10/1090 GA ČR - Grantová agentura ČR
    CEZAV0Z40400503 - UFCH-W (2005-2011)
    UT WOS000287624700017
    DOI10.1021/la104051z
    AnotaceFluorescent multi-ring-fused 2-pyridones, with chemical resemblance to other biologically active 2-pyridone systems, were solubilized in spherical micelles formed by the gangloiside Gm, and studied with respect to their spatial localization and rotational mobility. For this, electronic energy transfer between the multi-ring-fused 2-pyridone (donor) and BODIPY-FL-labeled G(M1) was determined, as well as their fluorescence depolarization. From the obtained efficiency of energy transfer to the acceptor group (BODIPY-FL), either localized in the polar or in the nonpolar part of the ganglioside, it has been possible to estimate the most likely localization of the multi-ring-fused 2-pyridones. The center of mass of the studied multi-ring-fused 2-pyridones are located at approximately 33 angstrom from the micellar center of mass, which corresponds to the internal hydrophobic hydrophilic interfacial region. At this location, the reorienting rates of the multi-ring-fused 2-pyridones are surprisingly slow with typical correlation times of 35-55 ns. No evidence was found for the formation of ground and excited state dimers, even when two monomers were forced to be near each other via a short covalent linker.
    PracovištěÚstav fyzikální chemie J.Heyrovského
    KontaktMichaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
    Rok sběru2013