Počet záznamů: 1
Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma
- 1.
SYSNO ASEP 0376021 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma Tvůrce(i) Altanerova, V. (SK)
Cihova, M. (SK)
Babič, Michal (UMCH-V) RID, ORCID
Rychly, B. (SK)
Ondicova, K. (SK)
Mravec, B. (SK)
Altaner, C. (SK)Zdroj.dok. International Journal of Cancer. - : Wiley - ISSN 0020-7136
Roč. 130, č. 10 (2012), s. 2455-2463Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova glioblastoma ; mesenchymal stem cells ; suicide gene therapy Vědní obor RIV CD - Makromolekulární chemie CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000301579800025 DOI 10.1002/ijc.26278 Anotace Human adipose tissue-derived MSCs to express the suicide gene cytosine deaminase::uracil phosphoribosyltransferase to treat intracranial rat C6 glioblastoma was tested. Experiments simulated conditions of future clinical application for high-grade glioblastoma therapy by direct injections of therapeutic stem cells into tumor. Genetically modified therapeutic stem cells showed the tumor tropism when injected to a distant intracranial site and effectively inhibited glioblastoma growth after 5-fluorocytosine (5-FC) therapy. Coadministration of C6 cells and therapeutic stem cells with delayed 5-FC therapy improved the survival in a therapeutic stem cell dose-dependent manner and induced complete tumor regression. Continuous intracerebroventricular delivery of 5-FC using osmotic pump reduced the dose of prodrug required for the same therapeutic effect, and along with repeated administration of therapeutic stem cells increased the survival time without any detectable adverse effects. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2013
Počet záznamů: 1