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Physiotherapy as an immunoactive therapy? A pilot study

SYSNO ASEP	0369644
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Physiotherapy as an immunoactive therapy? A pilot study
Tvůrce(i)	Řasová, K. (CZ) Doležil, D. (CZ) Kalistová, H. (CZ) Kučera, P. (CZ) Juzová, O. (CZ) Zimová, D. (CZ) Medová, E. (CZ) Jandová, D. (CZ) Tintěra, J. (CZ) Ibrahim, I. (CZ) Zvára, Karel (UIVT-O) Bičíková, M. (CZ) Martinková, Patrícia (UIVT-O)_{SAI, RID, ORCID}
Zdroj.dok.	Neuroendocrinology Letters - ISSN 0172-780X Roč. 33, č. 1 (2012), s. 67-75
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	SE - Švédsko
Klíč. slova	multiple sclerosis ; physiotherapy ; facilitation ; humoral and cellular immunity ; immunomodulation ; dehydroepiandrosterone
Vědní obor RIV	EC - Imunologie
CEP	1M06014 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z10300504 - UIVT-O (2005-2011)
UT WOS	000208852500013
EID SCOPUS	84982298860
Anotace	The aim of this study was to confirm the immunoregulatory and anti-inflammatory changes in the immunologic profile after two months of the facilitation physiotherapy in patients with multiple sclerosis (MS); and to determine whether the changes in the immunologic profile correlate with the changes in dehydroepiandrosterone, the brain microstructure and clinical functions. A group of 12 MS patients was examined twice: at the beginning and 2 months later after the patients had undergone the facilitation therapy. Standardized tests evaluating chosen clinical functions (balance, righting, equilibrium and protective reactions, tremor, dysdiadochokinesis, dysmetry, fine hand function and walking), immune parameters (parameters of the humoral and cellular immunity), dehydroepiandrosterone and diffusion tensor imaging (the fractional anisotropy, mean diffusivity) were measured. The patients underwent the facilitation physiotherapy in two sessions lasting two hours each week for two months. All clinical and diffusion tensor imaging parameters significantly improved following the therapy. Without the correction for multiple comparisons, there were significant changes in the IgG, IgG1 subclasses, in the numbers of Neutrophils and Lymphocytes, the T cells (CD3+) absolute number, the T cytotoxic subpopulation (CD3+CD8+) absolute number, B cells (CD19+) and the Natural killer cells. In addition, there was a significant correlation between the changes in the clinical functions and the changes in IgG1, and between the changes in the mean diffusivity and the changes in CD3+CD8+ absolute. The changes in the immune parameters and the mentioned correlations were not significant in view of the number of comparisons and thus necessitate further validation. No changes in the dehydroepiandrosterone concentration after the therapy were confirmed. The study suggests new possibilities of physiotherapy to influence the psycho–neuro–endocrine– immune response in MS patients.
Pracoviště	Ústav informatiky
Kontakt	Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800
Rok sběru	2013

Počet záznamů: 1