Počet záznamů: 1
Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma
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SYSNO ASEP 0369516 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma Tvůrce(i) Santarelli, L. (IT)
Strafella, E. (IT)
Staffolani, S. (IT)
Amati, M. (IT)
Emanuelli, M. (IT)
Sartini, D. (IT)
Pozzi, V. (IT)
Carbonari, D. (IT)
Bracci, M. (IT)
Pignotti, E. (IT)
Mazzanti, P. (IT)
Sabbatini, A. (IT)
Ranaldi, R. (IT)
Gasparini, S. (IT)
Neužil, Jiří (BTO-N) RID
Tomasetti, M. (IT)Zdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 6, č. 4 (2011), e18232Poč.str. 9 Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Malignant pleural mesothelioma ; microRNAs ; soluble mesothelin-related peptides Vědní obor RIV EB - Genetika a molekulární biologie CEP GA204/08/0811 GA ČR - Grantová agentura ČR CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000289058300007 DOI 10.1371/journal.pone.0018232 Anotace Improved detection methods for diagnosis of malignant mesothelioma (MM) are essential for detection and treatment. miRNAs isolated from fresh-frozen biopsies of MM patients were tested for the expression of 88 types of miRNA involved in cancerogenesis. Three significantly downregulated miRNAs were assayed in cancerous tissue and adjacent non-cancerous tissue sample pairs collected from 27 formalin-fixed, paraffin-embedded MM tissues by quantitative RT-PCR. Only miR-126 remained downregulated in the malignant tissues. The performance of the selected miR-126 as biomarker was evaluated in serum samples of asbestos-exposed subjects and MM patients and compared with controls. MiR-126 was not affected by asbestos exposure, whereas it was found associated with VEGF serum levels. Levels of miR-126 in serum, and its levels in patients' serum in association with a specific marker of MM, SMRPs, correlate with subjects at high risk to develop MM. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1