Počet záznamů: 1  

Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis

  1. 1.
    SYSNO ASEP0369504
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAsbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis
    Tvůrce(i) Tomasetti, M. (IT)
    Amati, M. (IT)
    Nocchi, L. (IT)
    Saccucci, F. (IT)
    Strafella, E. (IT)
    Tarquini, L.M. (IT)
    Carbonari, D. (IT)
    Alleva, R. (IT)
    Borghi, B. (IT)
    Neužil, Jiří (BTO-N) RID
    Bracci, M. (IT)
    Santarelli, L. (IT)
    Zdroj.dok.MUTAGENESIS - ISSN 0267-8357
    Roč. 26, č. 5 (2011), s. 585-591
    Poč.str.7
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaAsbestos exposure ; poly(ADP-ribose) polymerase-1 ; malignant mesothelioma
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEZAV0Z50520701 - BTO-N (2007-2013)
    UT WOS000294554600002
    DOI10.1093/mutage/ger020
    AnotaceAsbestos is known to induce malignant mesothelioma (MM). It is directly genotoxic by inducing DNA strand breaks. Poly(ADP-ribose) polymerase-1 (PARP1) is a protein with a function as a DNA damage sensor. To determine whether PARP1 is involved in asbestos-induced carcinogenesis, PARP1 expression and activity as well as DNA damage and repair were evaluated in circulating cells of asbestos-exposed subjects, MM patients and controls. Accumulation of the pre-mutagenic 8-hydroxy-2'-deoxyguanosine and elevated PARP1 expression were found both in asbestos-exposed subjects and MM patients. Although PARP1 was highly expressed, its activity was relatively low in circulating cells as well as in MM biopsies. Low DNA repair efficiency was observed in lymphocytes from MM patients. To mimic PARP1 dysfunction, PARP1 expression and activity were induced in immortalised mesothelial cells by their exposure to asbestos in the presence of a PARP1 inhibitor, which resulted in transformation of the cells.
    PracovištěBiotechnologický ústav
    KontaktMonika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
    Rok sběru2012
Počet záznamů: 1  

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