Počet záznamů: 1
Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death
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SYSNO ASEP 0369494 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death Tvůrce(i) Ralph, S.J. (AU)
Moreno-Sanchez, R. (MX)
Neužil, Jiří (BTO-N) RID
Rodriguez-Enriquez, S. (MX)Zdroj.dok. Pharmaceutical Research. - : Springer - ISSN 0724-8741
Roč. 28, č. 11 (2011), s. 2695-2730Poč.str. 35 Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Mitocans ; SDH/Complex II ; mitochondrial ROS production Vědní obor RIV CE - Biochemie CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000295697700006 DOI 10.1007/s11095-011-0566-7 Anotace Succinate:quinone reductase (SQR) of Complex II, occupying a unique central point in the mitochondrial respiratory system as a major source of electrons driving reactive oxygen species (ROS) production, is an ideal pharmaceutical target for modulating ROS levels in normal cells to prevent oxidative stress-induced damage or increase ROS in cancer cells, inducing cell death. Value of drugs like diazoxide to prevent ROS production, protecting normal cells, while vitamin E analogues promote ROS in cancer cells to kill them, is highlighted. We collate and discuss diverse sources of information relating to ROS production in different biological systems, focussing on evidence for SQR as main source of ROS production in mitochondria, particularly its relevance to protection from oxidative stress and to mitochondrial-targeted anticancer drugs (mitocans) as novel cancer therapies. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1