Počet záznamů: 1
The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?
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SYSNO ASEP 0369486 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection? Tvůrce(i) Zobalová, Renata (BTO-N) RID
Prokopová, Kateřina (BTO-N) ORCID
Stantic, M. (US)
Stapelberg, M. (US)
Dong, L.-F. (US)
Ralph, S.J. (US)
Akporiaye, E. (US)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Antioxidants & Redox Signaling. - : Mary Ann Liebert - ISSN 1523-0864
Roč. 15, č. 12 (2011), s. 2989-3002Poč.str. 13 Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Cancer stem-like cells ; protein CD133 ; apoptosis Vědní obor RIV EB - Genetika a molekulární biologie CEP GA204/08/0811 GA ČR - Grantová agentura ČR GA305/07/1008 GA ČR - Grantová agentura ČR CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000296588900006 DOI 10.1089/ars.2010.3785 Anotace Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors. Cancer stem-like cells (CSCs) have been characterized by a variety of markers, including the plasma membrane protein CD133, which is also indicative of the increase of stemness of cultured cancer cells growing as spheres. While the function of this protein has not yet been clearly defined, it may have a role in the stem-like phenotype of CSCs that cause (re-)initiation of tumors as well as their propagation. We hypothesize that CD133 selects for CSC survival against not only immunosurveillance mechanisms but also stress-induced apoptosis. High level of expression of CD133 may be a useful marker of more aggressive tumors that are recalcitrant toward established therapies. Compelling preliminary data indicate that drugs targeting mitochondria may be utilized as a novel, efficient cancer therapeutic modality. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1