Počet záznamů: 1
Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain
- 1.
SYSNO ASEP 0369481 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain Tvůrce(i) Rohlena, Jakub (BTO-N) RID, ORCID
Dong, L.-F. (AU)
Ralph, S.J. (AU)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Antioxidants & Redox Signaling. - : Mary Ann Liebert - ISSN 1523-0864
Roč. 15, č. 12 (2011), s. 2951-2974Poč.str. 24 Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Targets for anticancer drugs ; mitochondrial electron transport chain ; mitocans Vědní obor RIV EB - Genetika a molekulární biologie CEP KAN200520703 GA AV ČR - Akademie věd CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000296588900004 DOI 10.1089/ars.2011.3990 Anotace A group of compounds that induce mitochondrial destabilization affecting the physiology of cancer cells has been defined and termed 'mitocans.' We have placed these agents into several groups including hexokinase inhibitors, compounds targeting Bcl-2 proteins, thiol redox inhibitors, VDAC/ANT targeting drugs, electron transport chain-targeting drugs, lipophilic cations targeting the inner membrane, agents affecting the TCA cycle and drugs targeting mtDNA. Mitocans have a potential to prove efficient in suppressing various malignant diseases in a selective manner. They include compounds that offer promise to become clinically applied drugs. We redefine the individual classes of mitocans, providing examples of the various members of groups with a focus on agents targeting the electron transport chain. Even though ROS induction is important for the anticancer activity of many mitocans, the precise sequence of events is not yet fully clarified, and warrants further investigation. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1