Počet záznamů: 1
Mitochondrially Targeted alpha-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing
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SYSNO ASEP 0369479 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mitochondrially Targeted alpha-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing Tvůrce(i) Rohlena, Jakub (BTO-N) RID, ORCID
Dong, L.-F. (AU)
Klučková, Katarína (BTO-N) RID
Zobalová, Renata (BTO-N) RID
Goodwin, J. (AU)
Tilly, D. (AU)
Štursa, Jan (UOCHB-X)
Pecinová, Alena (FGU-C) RID, ORCID, SAI
Philimonenko, Anatoly (UMG-J)
Hozák, Pavel (UMG-J) RID, ORCID
Banerjee, J. (US)
Ledvina, Miroslav (UOCHB-X) RID
Sen, Ch.K. (US)
Houštěk, Josef (FGU-C) RID, ORCID
Coster, M.J. (AU)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Antioxidants & Redox Signaling. - : Mary Ann Liebert - ISSN 1523-0864
Roč. 15, č. 12 (2011), s. 2923-2935Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Analogs of alpha-tocopheryl succinate ; MitoVES ; inhibition of angiogenesis Vědní obor RIV EB - Genetika a molekulární biologie CEP 1M0520 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy KAN200520703 GA AV ČR - Akademie věd GA305/07/1008 GA ČR - Grantová agentura ČR GAP301/10/1937 GA ČR - Grantová agentura ČR GA204/08/0811 GA ČR - Grantová agentura ČR CEZ AV0Z50520701 - BTO-N (2007-2013) AV0Z50110509 - FGU-C (2005-2011) AV0Z4055905 - UOCHB-X AV0Z5052915 - UMG-J UT WOS 000296588900002 DOI 10.1089/ars.2011.4192 Anotace A plausible strategy to reduce tumor progress is the inhibition of angiogenesis. We tested the antiangiogenic potential of a mitochondrially targeted analog of alpha-tocopheryl succinate (MitoVES) with high propensity to induce apoptosis. MitoVES was found to efficiently kill proliferating endothelial cells (ECs) but not contact-arrested ECs or ECs deficient in mitochondrial DNA. It suppressed angiogenesis in vitro by inducing ROS accumulation in proliferating/angiogenic ECs. Resistance of arrested ECs was ascribed to the lower mitochondrial inner transmembrane potential compared with the proliferating ECs, thus resulting in the lower level of mitochondrial uptake of MitoVES. Shorter-chain homologs of MitoVES were less efficient in angiogenesis inhibition. MitoVES was found to suppress HER2-positive breast carcinomas in a transgenic mouse as well as inhibit tumor angiogenesis. The antiangiogenic efficacy of MitoVES was corroborated by its inhibitory activity on wound healing in vivo. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1