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The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply
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SYSNO ASEP 0369317 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply Tvůrce(i) Horáček, J. (CZ)
Tejkalová, H. (CZ)
Novák, T. (CZ)
Bubeníková-Valešová, V. (CZ)
Páleníček, T. (CZ)
Rambousek, L. (CZ)
Růžičková, Šárka (BTO-N) RID
Vaculín, Š. (CZ)
Hoeschl, C. (CZ)Zdroj.dok. Psychological Medicine. - : Cambridge University Press - ISSN 0033-2917
Roč. 41, č. 8 (2011), s. 1787-1789Poč.str. 3 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova serotonin ; proinflammatory ; cytokines Vědní obor RIV AN - Psychologie CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000292704400022 Anotace Psychiatric diseases are associated with elevated levels of pro-inflammatory cytokines in affected patients. Cytokines IL-1 and TNF- enhance the production of serotonin transporter (5-HT) thus, antidepressants could mediate their effect by downregulation of these cytokines. Therefore, we studied the influence of ketamine in male Wistar/Hann rats on IL-1 and TNF- and 5-HT activity in the blood and brain. Both cytokines increased up to 140% and 150% only in control animals, not in the ketamine group. Ketamine administration led to lower 5-HT levels in the hippocampus compared to controls (t=2.218, p<0.05). The hippocampal 5-HT levels correlated negatively with the basal TNF- and positively with the absolute and relative change of this cytokine in the whole sample, which suggests inhibition of IL-1 and TNF-activity. The mechanisms responsible for the interaction between the pro-inflammatory pathway, 5-HT and antidepressant effect of ketamine remain unknown Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2012
Počet záznamů: 1