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Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor
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SYSNO ASEP 0369138 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor Tvůrce(i) Jindřichová, Marie (FGU-C) RID
Khafizov, K. (DE)
Skorinkin, A. (RU)
Fayuk, D. (FI)
Bart, G. (FI)
Zemková, Hana (FGU-C) RID, ORCID
Giniatullin, R. (FI)Zdroj.dok. Journal of Neurochemistry. - : Wiley - ISSN 0022-3042
Roč. 119, č. 4 (2011), s. 676-685Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova purinergic receptors ; desensitization ; patch clamp Vědní obor RIV ED - Fyziologie CEP IAA500110910 GA AV ČR - Akademie věd CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000297020300002 DOI 10.1111/j.1471-4159.2011.07463.x Anotace Purinergic P2X receptors are ubiquitous, ligand-gated cationic channels activated by extracellular ATP. The P2X3 receptors, which are involved in nociception, are known for their very fast and complete desensitization, which persists for many minutes. Structural modeling followed by experimental validation of predictions suggested conserved tyrosine 37side chain is needed for the stabilization of the closed receptor state while kinetic modeling specifies that lack of Y37 results in destabilization of closed desensitized states Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2012
Počet záznamů: 1